Cardiometabolic & kidneyCohort study
Association between cumulative metabolic risk exposure and cardiovascular disease: a nationwide cohort of over 3.6 million young adults
- Retrospective cohort study
- nationwide
- population-based
Authors' conclusion
The risk of CVD increased in an exposure-dependent manner among young adults.
Study context
- Population
- Young adults (<40 years) with 2 biennial National Health Screening examinations, 2009–2012
- Participants
- 3,688,787 adults
- Exposure
- Cumulative metabolic syndrome (MetS) exposure categories vs MetS-free
- Outcome
- New CVD, including MI and ischaemic stroke
- Follow-up
- Median 7.7 years
Main finding
CVD incidence (per 1000 person-years)
Adjusted hazard ratio
1.94
95% CI 1.84–2.04
By group
MetS-persistent vs MetS-free
aHR 1.94 (95% CI 1.84–2.04)
As reported in the abstract
- Cardiovascular disease (CVD) overall
- 19 219 individuals (0.5%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Persistent elevated BP (MetS component) and CVD · greatest association among MetS components | 1.69 (1.63–1.76) | |
| 0.512Adjusted hazard ratio (log scale) |
Myocardial infarction (MI) and ischaemic stroke separately
- Tendency consistent in separate analyses of MI and ischaemic stroke
Original publication
Association between cumulative metabolic risk exposure and cardiovascular disease: a nationwide cohort of over 3.6 million young adults. Eur J Prev Cardiol. Published 29 February 2024. doi:10.1093/eurjpc/zwae088
Summarised from the published abstract; every number is checked against it