Association between delayed statin initiation after high LDL-cholesterol detection and cardiovascular risk in general health screening examinees
Main finding · MIResult — go to the resultHazard ratio 1.61 CI 1.37–1.89Authors' conclusion
Delayed initiation of statins following incidental detection of high LDL-C in general health screenings was associated with a progressively higher risk of MI. This association was more pronounced among younger individuals, males, or those without baseline diabetes.
Study context
- Population
- Adults aged ≥20 years undergoing annual health check-ups 2009–2012 with incidentally detected high low-density-lipoprotein cholesterol (LDL-C)5,058 myocardial infarction (MI) events
- Participants
- 508,284 adults
- Exposure
- Progressively delayed statin initiation after incidental high LDL-C detection vs normolipaemic
- Outcome
- Incident MI
- Follow-up
- Median 10.4 years
Main finding
MI
Hazard ratio
1.61
CI 1.37–1.89
P < 0.001 for trend
3rd year treatmentvs Normolipaemic
HR 1.61 (CI 1.37–1.89); P for trend < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Stratified and sensitivity analyses
- Significantly increasing trend in MI risk with delayed initiation remained consistent
MI, by age, sex and baseline DM (subgroups)
- Association more pronounced in young age, male, or without baseline DM
Original publication
Association between delayed statin initiation after high LDL-cholesterol detection and cardiovascular risk in general health screening examinees. Eur Heart J Qual Care Clin Outcomes. Published 10 September 2025. doi:10.
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