Association Between Duration of Resuscitation and Favorable Outcome After Out-of-Hospital Cardiac Arrest: Implications for Prolonging or Terminating Resuscitation
Authors' conclusion
Shorter resuscitation duration was associated with likelihood of favorable outcome at hospital discharge. Subjects with favorable case features were more likely to survive prolonged resuscitation up to 47 minutes.
Study context
- Population
- Consecutive adults with nontraumatic, EMS-treated OHCA
- Participants
- 11,368 adults
- Comparison
- Association of resuscitation duration with favourable outcome
- Primary endpoint
- Survival to hospital discharge with favorable outcome (mRS 0-3)
- Follow-up
- Hospital discharge
Methodological detailssingle-blind, multicentre, North American
- Single-blind
- Multicentre
- North American
Primary result
As reported in the abstract
Survival to discharge with mRS 0-3 per resuscitation duration
Adjusted OR, prehospital covariates
0.93
95% CI 0.92–0.95
Adjusted OR, inpatient covariates
0.97
95% CI 0.95–0.99
Survival with mRS 0-3 at discharge
905
8.0%
Further findings
ROSC and survival to discharge
- Achieved ROSC
- 4023 (35.4%)
- Survived to hospital discharge
- 1232 (10.8%)
- Distribution of CPR duration differed by outcome
- P < 0.00001
ROSC among those with eventual mRS 0-3
- 99% with eventual mRS 0-3 achieved ROSC for CPR duration up to
- 37.0 minutes (95% CI 34.9-40.9 minutes)
Favourable outcome after prolonged efforts (subgroups)
- Initial shockable rhythm, witnessed arrest and bystander CPR more likely to survive with favorable outcome after prolonged efforts (30-40 minutes)
Original publication
Association Between Duration of Resuscitation and Favorable Outcome After Out-of-Hospital Cardiac Arrest: Implications for Prolonging or Terminating Resuscitation. Circulation. Published 19 October 2016. doi:10.
Summarised from the published abstract; every number is checked against it