Cardiometabolic & kidneyCross-sectional study
Association Between Epicardial Adipose Tissue and Cardiac Dysfunction in Subjects with Severe Obesity
- Cross-sectional study
Authors' conclusion
Increased EAT thickness in subjects with obesity without known cardiac disease was independently associated with subclinical cardiac dysfunction.
Study context
- Population
- Subjects with BMI ≥35 kg/m² aged 35 to 65 years referred for bariatric surgery, without suspicion of or known cardiac disease
- Participants
- 186 subjects
- Exposure
- Epicardial adipose tissue (EAT) thickness tertiles
- EAT-1n = 62reference
- EAT-2n = 63
- EAT-3n = 61
- Outcome
- Association between EAT thickness and cardiac dysfunction (echocardiography and strain analyses)
Main finding
As reported in the abstract
- EAT thickness (per 1 mm increase) · global longitudinal strain (GLS) (%), independently associated decrease
- β coefficient −0.404; P = 0.002
- EAT thickness (per 1 mm increase) · LASct (%), independently associated decrease
- β coefficient −0.544; P = 0.027
- EAT-3 vs EAT-1 · cardiac dysfunction defined as GLS <18%
- OR 2.8; P = 0.013
- EAT-3 vs EAT-1 · cardiac dysfunction defined as LASct <14%
- OR 2.5; P = 0.045
Observational data: associations, not effects.
Original publication
Association Between Epicardial Adipose Tissue and Cardiac Dysfunction in Subjects with Severe Obesity. Eur J Heart Fail. Published 10 September 2023. doi:10.1002/ejhf.3011
Summarised from the published abstract; every number is checked against it