Acute cardiac care & resuscitation
Association Between Frailty Index Based on Laboratory Tests and All-Cause Mortality in Critically Ill Patients with Heart Failure
Authors' conclusion
In ICU patients diagnosed with HF, the FI-lab is a potent predictor of short-term and long-term mortality in critically ill patients with HF.
Study context
- Population
- Critically ill intensive care unit (ICU) patients with heart failure (HF)
- Participants
- 3,021 patients
- Exposure
- FI-lab quartiles Q4 vs Q1
- Outcome
- All-cause mortality
- Follow-up
- 28 days and 360 days
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Q4vs Q128-day mortality
1.66(1.28–2.15)
P < 0.001Q4vs Q1360-day mortality
1.48(1.23–1.8)
P < 0.001FI-lab per 0.01 increase28-day mortality, multivariable
1.02(1.01–1.03)
P < 0.001FI-lab per 0.01 increase360-day mortality, multivariable
1.02(1.01–1.02)
P < 0.001- Overall deaths within 28 days
- 838 (27.74%)
- Overall deaths within 360 days
- 1400 (46.34%)
- Higher FI-lab scores had significantly higher all-cause mortality (Kaplan-Meier)
- log-rank P < 0.001
Observational data: associations, not effects.
Further findings
Incremental predictive value added to classical disease severity scores · 28 and 360 days
- FI-lab significantly improved the predictive capability of classical disease severity scores
Original publication
Association Between Frailty Index Based on Laboratory Tests and All-Cause Mortality in Critically Ill Patients with Heart Failure. ESC Heart Fail. Published 9 July 2024. doi:10.
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