Prevention & lipidsCohort study
Association Between Hypertensive Disorders of Pregnancy, Lifestyle Factors, and Premature Cardiovascular Events
- Australian Longitudinal Study on Women's Health 1973-1978 cohort
- linked with medical records
- time-varying Cox proportional hazards models
Authors' conclusion
This study found that a HDP diagnosis was associated with pCV. Obesity and high saturated-fat intake were associated with increased pCV, whereas breastfeeding and high protein intake were associated with lower pCV. The impact of some risk factors on the development of pCV differs between women with and without HDP. These findings highlight the importance of prevention management in women with HDP.
Study context
- Population
- Young parous women with and without hypertensive disorders of pregnancyparous women, median follow-up 16.5 years
- Participants
- 10,368 women
- Exposure
- Association between lifestyle factors and premature (<50 years) cardiovascular (pCV) events in women with and without hypertensive disorders of pregnancy (HDP)
- HDPn = 1,493
Main finding
As reported in the abstract
pCV event · median follow-up: 16.5 years
- experienced a pCV event
- 4.3% (448/10,310)
- HDP, aHR
- 1.74; 95% CI: 1.32-2.31
- obesity, aHR
- 1.60; 95% CI: 1.19-2.15
- high saturated-fat intake (>319 g/day), aHR
- 1.67; 95% CI: 1.11-2.53
- Breastfeeding (>16 months), aHR
- 0.66; 95% CI: 0.49-0.89
- high protein intake (>90 g/day), aHR
- 0.65; 95% CI: 0.43-0.96
Observational data: associations, not effects.
Further findings
Smoking, Australian Recommended Food Score diet, and glycemic index with pCV events
- association differed in women with and without HDP
Original publication
Association Between Hypertensive Disorders of Pregnancy, Lifestyle Factors, and Premature Cardiovascular Events. JACC Adv. Published 31 August 2026. doi:10.1016/j.jacadv.2026.103187
Summarised from the published abstract; every number is checked against it