Cardio-oncology & otherDiagnostic or prognostic study
Association Between Inflammation and Risk of Cardiovascular Mortality in Cancer Survivors
- Multivariable analyses using competing-risk models
- UK Biobank
Authors' conclusion
This study demonstrates that chronic inflammation is significantly associated with cardiovascular mortality in cancer survivors. Future research should focus on whether targeting inflammatory pathways can reduce the burden of cardiovascular mortality in this population.
Study context
- Population
- UK Biobank participants with prior cancer and no active therapy (cancer survivors)UK Biobank participants with prior cancer and no active therapy
- Participants
- 15,420 participants
- Comparison
- C-reactive protein (CRP) levels >2 mg/L compared to CRP ≤2 mg/L
Performance
As reported in the abstract
Deaths among cancer survivors · median follow-up of 10.2 ± 1.9 years
Deaths among cancer survivors
1,167 (7.6%)
Cancer-related deaths
813
Cardiovascular deaths
103
Further findings
| Outcome | sHR (95% CI) | P value | |
|---|---|---|---|
| Cardiovascular death — CRP >2 mg/L vs CRP ≤2 mg/L · Unadjusted competing-risk analysis | 2.12 (1.40–3.21) | P < 0.001 | |
| Cardiovascular death — CRP >2 mg/L vs CRP ≤2 mg/L | 1.64 (1.07–2.50) | P = 0.023 | |
| 0.20.5125Subdistribution hazard ratio (log scale) |
- Cardiovascular death: adjusted for sociodemographic, lifestyle factors, and clinical characteristics
Subgroup analyses
- Subgroup analyses further confirmed the consistent finding
Original publication
Association Between Inflammation and Risk of Cardiovascular Mortality in Cancer Survivors. JACC Adv. Published 23 January 2026. doi:10.1016/j.jacadv.2025.102565
Summarised from the published abstract; every number is checked against it