Heart failure & cardiomyopathiesCohort study
Association between left ventricular longitudinal function and left atrial strain in left ventricular dysfunction
- retrospective
- CMR feature-tracking
Authors' conclusion
In a large cohort comprising both patients with LV dysfunction and HC, LA reservoir function quantified as LA-GLS was to a large extent determined by LV longitudinal function. LA function may not be an independent marker of global cardiac function for certain patient groups where diminished LA function can be a reflection of LV dysfunction.
Study context
- Population
- Patients with left ventricular (LV) dysfunction (including heart failure with reduced ejection fraction (HFrEF), candidates for cardiac resynchronization therapy (CRT) implantation, and IHD) and healthy controls who had undergone CMRpatients with LV dysfunction Three hundred and forty-two · healthy controls (HC) 19
- Exposure
- Association between LV longitudinal ventricular function and left atrial (LA) strain using CMR feature-tracking; LV dysfunction group compared to HC
- LV dysfunctionn = Three hundred and forty-two
- HCn = 19
Main finding
As reported in the abstract
LA-GLS
LV dysfunction
12
± 8 · %
HC
19
± 7
P < 0.001
Observational data: associations, not effects.
Further findings
LV-AVPD · reductions in LV dysfunction group
P < 0.001
| Outcome | LV dysfunction | HC | P value |
|---|---|---|---|
| LV-GLS · reductions in LV dysfunction group | −10 ± 5 % | −19 ± 3 | P < 0.001 |
Coefficient of determination (r2) with LA-GLS
- r2 between LV global longitudinal strain (LV-GLS) and LA-GLS, whole cohort
- .40 (95% CI 0.32-0.48)
- r2 between LV-AVPD and LA-GLS
- 0.39 (95% CI 0.31-0.47)
Original publication
Association between left ventricular longitudinal function and left atrial strain in left ventricular dysfunction. ESC Heart Fail. Published 10 February 2026. doi:10.1093/eschf/xvag046
Summarised from the published abstract; every number is checked against it