Prevention & lipidsCohort study
Association Between Lipoprotein(a) and Cardiac Remodeling Across Race and Ethnicity in the Multi-Ethnic Study of Atherosclerosis
- prospective multi-ethnic cohort study
- 6 sites in the United States
- multivariable regression
Authors' conclusion
Elevated Lp(a) levels were independently associated with maladaptive left ventricular and left atrial remodeling in Hispanic adults over a decade, while no statistically significant relationships were observed in White, Black, and Chinese participants. This suggests a unique susceptibility of Hispanic individuals to Lp(a)-mediated cardiovascular remodeling, independent of ischemic pathways.
Study context
- Population
- Individuals without a history of cardiovascular disease on enrollment (2000–2002), with baseline Lp(a) measurements and cardiac magnetic resonance imaging at baseline and 10-year follow-upparticipants included
- Participants
- 2,366 individuals
- Exposure
- Lp(a) (per SD log and terciles) and longitudinal changes in left ventricular and atrial structure and function over a decade across different racial/ethnic groups
Main finding
As reported in the abstract
Left ventricular end-systolic volume index, Hispanic subjects · over a decade
β
0.60
95% CI 0.02–1.18
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) |
|---|---|
| Left atrial minimum volume index, Hispanic subjects · over a decade · increase | 0.81 (0.09–1.52) |
| Left ventricular ejection fraction, Hispanic subjects · over a decade · decline | −0.75 (−1.34 to −0.17) |
| Total left atrial emptying fraction, Hispanic subjects · over a decade · decline | −1.17 (−2.09 to −0.24) |
Associations in White, Black, or Chinese participants
- No significant associations were seen in White, Black, or Chinese participants
Baseline characteristics
- average age
- 60±9
- women
- 53%
- White
- 43%
- Black
- 24%
- Hispanic
- 21%
- Chinese
- 12%
Sensitivity analyses
- Findings persisted after adjusting for coronary artery calcium, interim myocardial infarction, and atrioventricular decoupling, and with race-specific Lp(a) terciles
Original publication
Association Between Lipoprotein(a) and Cardiac Remodeling Across Race and Ethnicity in the Multi-Ethnic Study of Atherosclerosis. Circ Popul Health Outcomes. Published 20 February 2026. doi:10.1161/circoutcomes.125.013261
Summarised from the published abstract; every number is checked against it