Aortic & peripheral vascular diseaseCohort study
Association between lipoprotein(a) and cardiovascular events in patients with peripheral artery disease: the Mass General Brigham Lp(a) registry
- Retrospective cohort study
- registry
- two tertiary care centres
Authors' conclusion
Elevated Lp(a) in patients with PAD was associated with an increased risk of both MACE and MALE.
Study context
- Population
- Patients with peripheral artery disease (PAD) and Lp(a) measured at two tertiary care centres, 2000–2019 (Mass General Brigham (MGB) Lp(a) registry)39% female
- Participants
- 3,757 patients
- Exposure
- Lp quartiles Q2–Q4 vs Q1
- Outcome
- MACE (CV death, MI or coronary revascularization) and MALE (peripheral revascularization, acute limb ischaemia or major lower extremity amputation)
Main finding
As reported in the abstract
MACE and MALE by Lp(a) quartile
Major adverse cardiovascular events (MACE), third quartile vs first quartile: 24% increased hazard (adj. HR), P = 0.005
1.24
MACE, fourth quartile vs first quartile: 30% increased hazard (adj. HR), P = 0.001
1.30
MALE, fourth quartile vs first quartile: 19% greater hazard (adj. HR), P = 0.043
1.19
Observational data: associations, not effects.
Original publication
Association between lipoprotein(a) and cardiovascular events in patients with peripheral artery disease: the Mass General Brigham Lp(a) registry. Eur J Prev Cardiol. Published 18 September 2025. doi:10.1093/eurjpc/zwaf475
Summarised from the published abstract; every number is checked against it