Cardiometabolic & kidneyCohort study
Association Between Liver Fibrosis, Plasma Volume Status, and Cardiovascular Mortality: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases
- Retrospective cohort study
Authors' conclusion
Systemic congestion may partially contribute to the progression of liver fibrosis, and advanced liver fibrosis increases cardiovascular mortality rates, independent of congestion, and heart failure-related mortality was more prominent than ischaemic heart disease-related mortality.
Study context
- Population
- Health checkup participants in the Hiroshima Study on Glucose Metabolism and CVD (mean age 69.7 years, 49.1% women)
- Participants
- 8,689 participants
- Exposure
- High or indeterminate vs low FIB-4 index
- Outcome
- CV mortality
- Follow-up
- Median 9.3 years
Main finding
As reported in the abstract
Hazard ratio
2.34
95% CI 1.78–3.06
By group
High FIB-4 vs Low FIB-4
HR 2.34 (95% CI 1.78–3.06)
- CV deaths
- 387 (4.5%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Cardiac and cerebrovascular mortality — High FIB-4 vs Low FIB-4 · cardiac · adjusted for PVS | 2.43 (1.75–3.39) | |
| Cardiac and cerebrovascular mortality — High FIB-4 vs Low FIB-4 · cerebrovascular · adjusted for PVS | 2.18 (1.37–3.48) | |
| 0.20.5125Hazard ratio (log scale) |
HF- and ischaemic heart disease-related mortality, indeterminate FIB-4
- HF-related mortality increased in the indeterminate FIB-4 group, ischaemic heart disease-related mortality not
Plasma volume status (PVS) and FIB-4 index at baseline
- PVS modestly but significantly associated with FIB-4 index
Original publication
Association Between Liver Fibrosis, Plasma Volume Status, and Cardiovascular Mortality: The Hiroshima Study on Glucose Metabolism and Cardiovascular Diseases. Eur J Heart Fail. Published 4 May 2025. doi:10.1002/ejhf.3677
Summarised from the published abstract; every number is checked against it