Arrhythmias & electrophysiologyCohort study
Association Between Mosaic Loss of Y Chromosome and Atrial Fibrillation
- large hospital-based biobank cohort
Authors' conclusion
mLoY is independently associated with a higher prevalence of AF and higher mortality among AF patients. These findings support mLoY as a potential biomarker for cardiovascular risk stratification in aging men and highlight fibrosis as a key mechanistic pathway warranting further investigation.
Study context
- Population
- Male participants aged ≥20 years from the Mass General Brigham Biobank with available genomic and clinical dataAtrial fibrillation (AF) patients 2,940 · control participants 14,976
- Participants
- 17,916 male participants
- Exposure
- Associations among mLoY, AF, and mortality
- AF patientsn = 2,940
- control participantsn = 14,976
Main finding
As reported in the abstract
mLoY prevalence
- mLoY prevalence was higher in AF patients across both classification methods
Observational data: associations, not effects.
Further findings
AF
| Comparison | adjusted OR (95% CI) | |
|---|---|---|
| Y chromosome value <−0.1 · 25% increased odds of AF; adjusted for age and comorbidities | 1.25 (1.01–1.55) | |
| 0.512Adjusted odds ratio (log scale) |
All-cause mortality among patients with AF
| Comparison | adjusted OR (95% CI) | |
|---|---|---|
| mLoY | 1.37 (1.06–1.79) | |
| 0.512Adjusted odds ratio (log scale) |
- All-cause mortality among patients with AF: 37% higher risk of all-cause mortality, among patients with AF
Original publication
Association Between Mosaic Loss of Y Chromosome and Atrial Fibrillation. JACC Clin Electrophysiol. Published 8 June 2026. doi:10.1016/j.jacep.2026.05.013
Summarised from the published abstract; every number is checked against it