Heart failure & cardiomyopathiesCohort study
Association Between Occupational Physical Work Exposure and Wild-Type Transthyretin Cardiomyopathy
- matched general population cohort
- matched 1:5 by age and sex
- conditional Poisson regression
Authors' conclusion
ATTRwt-CM was associated with greater occupational upper-body mechanical stress. While a causal relationship cannot be established due to study design, the results are hypothesis generating for the development of ATTRwt-CM. Additionally, ATTRwt-CM patients had a greater burden of orthopedic and cardiovascular comorbidities including increased cardiovascular mortality.
Study context
- Population
- Patients diagnosed with ATTRwt-CM between 2016 and 2023 and controls randomly selected from the Danish general populationpatients with ATTRwt-CM 258 · controls 1,290
- Participants
- 258 vs 1,290
- Exposure
- patients with ATTRwt-CM compared with a matched general population cohort
- ATTRwt-CMn = 258
- controlsn = 1,290reference
Main finding
As reported in the abstract
Cardiovascular and orthopedic comorbidities
- ATTRwt-CM patients had a higher prevalence of cardiovascular comorbidities (atrial fibrillation and aortic stenosis) and orthopedic conditions (carpal tunnel syndrome, lumbar spinal stenosis, and lower limb arthrosis)
Observational data: associations, not effects.
Further findings
| Outcome | ATTRwt-CM | controls | IRR (95% CI) | |
|---|---|---|---|---|
| Agricultural employment | 28% | 8% | 3.35 (2.55–4.39) | |
| Cardiovascular mortality · Three-year | 13% | 5% | 3.38 (1.97–5.83) | |
| All-cause mortality · Three-year | 33% | 21% | 1.93 (1.48–2.50) | |
| 0.20.5125Incidence rate ratio (log scale) |
Upper body mechanical workload exposures
- greater upper body mechanical workload exposures were more common among patients with ATTRwt-CM than among controls
Original publication
Association Between Occupational Physical Work Exposure and Wild-Type Transthyretin Cardiomyopathy. JACC Adv. Published 23 February 2026. doi:10.1016/j.jacadv.2026.102619
Summarised from the published abstract; every number is checked against it