Arrhythmias & electrophysiologyCohort study
Association between remnant cholesterol and cardiac conduction block: A prospective cohort study
- prospective cohort study
Authors' conclusion
Both low and high cumulative average RC levels were associated with an increased risk of CCB and its major subtypes, suggesting the importance of maintaining RC within an optimal range.
Study context
- Population
- Participants of the Kailuan study with serially measured remnant cholesterol (RC) levels78.12% men, mean age 51.55 ± 12.53 years
- Participants
- 80,853 participants
- Exposure
- Cumulative average RC levels and the risk of cardiac conduction block (CCB)
Main finding
As reported in the abstract
Incident CCB · median follow-up of 10.40 years
incident CCB cases
3203
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CCB — RC of <0.76 mmol/L vs RC levels of 0.76-1.05 mmol/L · multivariable-adjusted | 1.55 (1.39–1.72) | |
| CCB — RC of ≥1.40 mmol/L vs RC levels of 0.76-1.05 mmol/L · multivariable-adjusted | 1.78 (1.61–1.97) | |
| 0.512Hazard ratio (log scale) |
- CCB: These findings remained consistent across multiple sensitivity analyses.
Association between cumulative average RC levels and risk of CCB
- U-shaped association
- P nonlinearity = .001
Major subtypes of CCB (atrioventricular block, left bundle branch block, right bundle branch block)
- Similar U-shaped associations
Original publication
Association between remnant cholesterol and cardiac conduction block: A prospective cohort study. Heart Rhythm. Published 20 January 2026. doi:10.1016/j.hrthm.2026.01.019
Summarised from the published abstract; every number is checked against it