Valvular & structural heart disease
Association between remnant cholesterol and progression of bioprosthetic valve degeneration
Authors' conclusion
Elevated RC is independently associated with faster progression of bioprosthetic valve degeneration and increased risk of all-cause mortality or aortic valve re-intervention.
Study context
- Population
- Patients a median of 7.0 years (IQR 5.1–9.2) after surgical aortic valve replacement121 with follow-up visit
- Participants
- 203 participants
- Exposure
- Remnant cholesterol (RC) >23.7 mg/dL vs RC ≤23.7 mg/dL
- Outcome
- Annualized change in aortic valve calcium density (AVCd)
- Follow-up
- 3-year follow-up
Main finding
As reported in the abstract
Annualized AVCd progression rate
Curvilinear relationship of RC with aortic valve calcium density (AVCd) progression; increased progression when RC >23.7 mg/dL
P = 0.008
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality or aortic valve re-intervention · median 8.8 (8.7-9.6) yearsIndependently associated | 1.98 (1.31–2.99) | P = 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
- All-cause mortality or aortic valve re-intervention: 99 deaths and 46 re-interventions in 133 patients
Original publication
Association between remnant cholesterol and progression of bioprosthetic valve degeneration. Eur Heart J Cardiovasc Imaging. Published 6 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it