Heart failure & cardiomyopathiesCohort study
Association Between Secondhand Smoke Exposure and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis (MESA)
- Prospective cohort study
- multivariable Cox proportional hazards regression
Authors' conclusion
Secondhand smoke exposure reflected by modestly increased urinary cotinine (>7.07 ng/ml) rather than self-report in non-active smokers was associated with a 40-50% higher risk of any HF event.
Study context
- Population
- Non-active smokers aged 45–84 years free of known CVD and heart failure (HF) at baseline, MESA (2000–2002)cotinine subset 3376
- Participants
- 5,548 smokers
- Exposure
- Secondhand smoke (SHS) exposure vs no exposure
- Outcome
- Incident HF
- Follow-up
- Median 17.7 years
Main finding
As reported in the abstract
median 17.7 years
Hazard ratio (95% CI)P value
Highest SHS tertile vs SHS unexposedself-report cohort; 353 HF events
0.70(0.49–1.00)
P = 0.052Detectable cotinine vs Undetectable cotininecohort subset; 196 HF events
1.45(1.03–2.06)
P = 0.034Observational data: associations, not effects.
Further findings
HF risk by age, sex, race/ethnicity, past smoking status (subgroups)
- No significant heterogeneity
Original publication
Association Between Secondhand Smoke Exposure and Incident Heart Failure: The Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Heart Fail. Published 30 January 2024. doi:10.1002/ejhf.3155
Summarised from the published abstract; every number is checked against it