HypertensionSecondary analysis
Association Between Social Determinants of Health and Adherence to Antihypertensive Medications in US Patients With Uncontrolled, Treated Hypertension
- secondary analysis of a pragmatic trial
- 12 primary care clinics
- 1:3 propensity score matching
- linked electronic health record and pharmacy dispensing data
Authors' conclusion
SDoH may have important associations with antihypertensive medication adherence. Identifying and addressing social needs in primary care practice may help improve hypertension control and health outcomes.
Study context
- Population
- Patients with uncontrolled hypertension (≥140/90 mm Hg) across primary care clinics in a large healthcare system in Illinoispatients included
- Participants
- 5,386 patients
- Comparison
- each social determinants of health (SDoH) and being adherent
Primary result
As reported in the abstract
Being adherent to antihypertensive medications (proportion of days covered ≥80%) · 1-year follow-up period
Each group vs not experiencing financial resource strainOdds ratio (95% CI)
financial resource strain45% lower odds; after matching
0.55(0.39–0.79)
transportation needsnot significantly associated
0.94(0.61–1.45)
food insecuritynot significantly associated
0.89(0.69–1.16)
Secondary outcomes
| Outcome | difference (95% CI) | |
|---|---|---|
| Absolute proportion of days covered (secondary outcome) · secondary outcome | −5.8% (−10.4% to −1.2%) | |
| −15−10−505Difference (linear scale) |
- Absolute proportion of days covered (secondary outcome): significantly lower proportion of days covered; after matching
SDoH prevalence and overall adherence (descriptive)
- reported transportation needs
- 2.8%
- reported financial resource strain
- 3.4%
- reported food insecurity
- 6.8%
- patients adherent
- 2955 (54.9%)
Original publication
Association Between Social Determinants of Health and Adherence to Antihypertensive Medications in US Patients With Uncontrolled, Treated Hypertension. Circ Popul Health Outcomes. Published 17 April 2026. doi:10.1161/circoutcomes.125.012932
Summarised from the published abstract; every number is checked against it