Acute cardiac care & resuscitationCohort study
Association between the first post-resuscitation partial pressure of arterial carbon dioxide and neurologic outcomes in children with out-of-hospital cardiac arrest: a multicenter retrospective cohort study
- multicenter retrospective cohort study
- propensity score-based overlap weighting
- hospital-clustered weighted generalized estimating equation models
Authors' conclusion
In this multicenter study of pediatric OHCA, we found no clear evidence of an independent association between first post-ROSC PaCO2 category and 30-day outcomes, although estimates were imprecise.
Study context
- Population
- Pediatric patients aged <18 years with out-of-hospital cardiac arrest and return of spontaneous circulation (ROSC), Japanese OHCA registry (2014–2022), first post-ROSC blood gas sampling within 60 minpatients in the primary analysis
- Participants
- 215 patients
- Exposure
- Hypocapnia or hypercapnia vs normocapnia
- hypocapnian = 27
- normocapnian = 39reference
- hypercapnian = 149
- Outcome
- Favorable neurologic outcome (Pediatric Cerebral Performance Category score of 1-3)
- Follow-up
- 30 days
Main finding
As reported in the abstract
Each group vs normocapniaAdjusted odds ratio (95% CI)
hypocapnia
0.83(0.13–5.14)
hypercapnia
1.46(0.25–8.68)
- Favorable neurologic outcome at 30 days, all patients
- 41 (19.1%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| 30-day survival (secondary outcome) · 30 days — hypocapnia vs normocapnia · After adjustment | 1.46 (0.26–8.01) | |
| 30-day survival (secondary outcome) · 30 days — hypercapnia vs normocapnia · After adjustment | 0.36 (0.09–1.46) | |
| 0.050.21520Adjusted odds ratio (log scale) |
- 30-day survival (secondary outcome) — 30-day survival, all patients
- 92 (42.8%)
Original publication
Association between the first post-resuscitation partial pressure of arterial carbon dioxide and neurologic outcomes in children with out-of-hospital cardiac arrest: a multicenter retrospective cohort study. Resuscitation. Published 11 September 2026. doi:10.1016/j.resuscitation.2026.111306
Summarised from the published abstract; every number is checked against it