Cardiometabolic & kidneyCohort study
Association between the life's essential 8 health behaviors and prognosis in patients with advanced cardiovascular-kidney-metabolic syndrome
- Cohort study (NHANES)
Authors' conclusion
The LE8, particularly its health behavior, is independently associated with mortality in advanced CKM syndrome.
Study context
- Population
- Patients with advanced cardiovascular-kidney-metabolic (CKM) syndrome, NHANES2,629 with advanced CKM syndrome
- Participants
- 10,321 patients
- Exposure
- LE8 score, health behavior and health factor components vs mortality
- Outcome
- Mortality risk (all-cause, CV, CKM-related)
- Follow-up
- median 78-month follow-up
Main finding
As reported in the abstract
Mortality in advanced CKM syndrome
HR
- Health behavior score, per 10-point increase · all-cause mortality
- 0.80
- Health behavior score, per 10-point increase · CV mortality
- 0.83
- Health behavior score, per 10-point increase · CKM-related mortality
- 0.82
- Moderate CVH vs High CVH · health behavior; all-cause mortality
- 2.08
- Moderate CVH vs High CVH · health behavior; CV mortality
- 1.88
- Moderate CVH vs High CVH · health behavior; CKM-related mortality
- 1.94
- Low CVH vs High CVH · health behavior; all-cause mortality
- 3.25
- Low CVH vs High CVH · health behavior; CV mortality (as printed)
- 253
- Low CVH vs High CVH · health behavior; CKM-related mortality
- 2.89
Observational data: associations, not effects.
Further findings
| Outcome | OR |
|---|---|
| Advanced CKM syndrome risk — LE8 score, per 10-point increase | 0.85 |
| Advanced CKM syndrome risk — Low CVH vs High CVH | 2.05 |
Original publication
Association between the life's essential 8 health behaviors and prognosis in patients with advanced cardiovascular-kidney-metabolic syndrome. Eur J Prev Cardiol. Published 17 July 2025. doi:10.1093/eurjpc/zwaf443
Summarised from the published abstract; every number is checked against it