The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium
Authors' conclusion
Childhood and adolescent HDL-C were prospectively and inversely associated with adult ASCVD, suggesting that low HDL-C could be a risk marker of adult ASCVD.
Study context
- Population
- Children in the International Childhood Cardiovascular Cohort (i3C) Consortium with childhood HDL-C and adult atherosclerotic cardiovascular disease (ASCVD) follow-up779 ASCVD + 784 imputed events
- Participants
- 38,589 children
- Exposure
- Childhood HDL-C levels and trajectories vs adult ASCVD
- Outcome
- Adult ASCVD events:
- Self-reports adjudicated by medical records
- Death registries
Methodological detailsmulticohort consortium (i3C)
- Multicohort consortium (i3C)
Main finding
As reported in the abstract
Adult ASCVD
Each group vs consistently normalHazard ratio (95% CI)
Normal to low
1.38(1.04–1.82)
Consistently low
1.94(1.45–2.63)
- Higher HDL-C z-scores in childhood, early childhood and adolescence associated with lower adult ASCVD risk (HR)
- 0.81-0.82
Observational data: associations, not effects.
Original publication
The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium. Eur J Prev Cardiol. Published 5 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it