Association of high-sensitivity cardiac troponin I levels below the sex-specific 99th percentile with late-life dementia: the Perth Longitudinal Study of Ageing Women
Main finding · Incident LLD events, including LLD hospitalisation or deathResult — go to the resultAdjusted hazard ratio 1.88 95% CI 1.22–2.91Authors' conclusion
Among older women, hs-cTnI levels below the sex-specific 99th percentile for myocardial injury were associated with an increased risk of LLD events over 14.5 years. These findings suggest that hs-cTnI may identify older women at higher risk of LLD, capturing both cardiovascular and brain health vulnerability in older age.
Study context
- Population
- Community-dwelling women aged ≥70 years without prior late-life dementia (LLD) and with hs-cTnI <15.6 ng/Lcommunity-dwelling women, hs-cTnI stratified into quartiles
- Participants
- 986 women
- Exposure
- Highest (Q4) vs lowest (Q1) quartile of hs-cTnI below the sex-specific 99th percentile
- Outcome
- Incident LLD events, including LLD hospitalisation or death
- Follow-up
- 14.5 years
Methodological detailsmultivariable-adjusted Cox models, restricted cubic splines, linked health records
- Multivariable-adjusted Cox models
- Restricted cubic splines
- Linked health records
Main finding
As reported in the abstract
Adjusted hazard ratio
1.88
95% CI 1.22–2.91
Q4vs Q1
adjusted HR 1.88 (95% CI 1.22–2.91)
- LLD events
- n=174, 17.7%
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| LLD hospitalisation · 14.5 years | 1.65 (1.04–2.64) | |
| LLD death · 14.5 years | 2.27 (1.13–4.59) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- LLD hospitalisation — hospitalisations
- n=155, 15.7%
- LLD death — deaths
- n=68, 6.9%
Baseline age
- Mean (±SD) age
- 75.2±2.7 years
Original publication
Association of high-sensitivity cardiac troponin I levels below the sex-specific 99th percentile with late-life dementia: the Perth Longitudinal Study of Ageing Women. Heart. Published 19 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →