Heart failure & cardiomyopathiesCohort study
Association of a mild or an important decline in left ventricular ejection fraction with ventricular tachyarrhythmias, sudden cardiac death and all-cause death in heart failure with preserved ejection fraction: A report from the CHART-2 Study
- Retrospective cohort study
- registry-based (CHART-2 Study)
Authors' conclusion
In patients with HFpEF, even a mild decline in LVEF was associated with a higher risk of ventricular tachyarrhythmia, sudden cardiac death, and all-cause death.
Study context
- Population
- Patients with HF and left ventricular ejection fraction (LVEF) ≥ 50% at registration (heart failure with preserved ejection fraction (HFpEF)), 73 years, 39% female
- Participants
- 1,453 patients
- Exposure
- LVEF <50% vs LVEF ≥50% at 1-year follow-up
- LVEF ≥ 50%n = 1,316reference
- LVEF 36-50%n = 120
- LVEF ≤ 35%n = 17
- Outcome
- Composite of:
- Ventricular tachycardia
- Ventricular fibrillation
- Sudden cardiac death
- Follow-up
- Median 7.9 years
Main finding
Composite of:
Adjusted hazard ratio
1.99
95% CI 1.04–3.79
P = 0.04
By group
LVEF < 50% vs LVEF ≥ 50%
adjusted HR 1.99 (95% CI 1.04–3.79); P = 0.04
As reported in the abstract
- Patients with composite event overall
- 79 (5.4%)
Observational data: associations, not effects.
Further findings
| Outcome | LVEF ≥ 50% | LVEF 36-50% | LVEF ≤ 35% | P value |
|---|---|---|---|---|
| All-cause death · median follow-up 7.9 years | 51.8% | Not reported in the abstract | Not reported in the abstract | P = 0.006 |
- All-cause death: LVEF < 50% 62.8%
Original publication
Association of a mild or an important decline in left ventricular ejection fraction with ventricular tachyarrhythmias, sudden cardiac death and all-cause death in heart failure with preserved ejection fraction: A report from the CHART-2 Study. Europace. Published 29 August 2025. doi:10.1093/europace/euaf184
Summarised from the published abstract; every number is checked against it