Coronary disease & ACSCohort study
Association of Adverse Clinical Outcomes With Peri-Infarct Ischemia Detected by Stress Cardiac Magnetic Imaging
- Prospective cohort study
- multicenter
- consecutive patients
Authors' conclusion
Peri-infarct ischemia is a novel and robust prognostic marker of adverse cardiovascular events.
Study context
- Population
- Consecutive patients undergoing stress CMR, expanded cohort of the multicenter SPINS study
- Participants
- 3,915 patients
- Exposure
- Peri-infarct ischemia vs no infarct and no ischemia
- Peri-infarct ischemian = 382
- Outcome
- Acute MI and CV death
- Follow-up
- Median 5.3 years (Q1-Q3: 3.9-7.2 years)
Main finding
Primary events:
· median 5.3 years
HRadjusted
1.72
95% CI 1.23–2.41
P < 0.001
By group
As reported in the abstract
- Primary events overall
- 406 (10.4%)
Observational data: associations, not effects.
Further findings
| Outcome | HRadjusted (95% CI) | P value |
|---|---|---|
| Secondary events (primary events, unstable angina hospitalization, HF hospitalization, late CABG) · median 5.3 years | 1.71 (1.32–2.20) | P < 0.001 |
- Secondary events (primary events, unstable angina hospitalization, HF hospitalization, late CABG) — Secondary events overall
- 745 (19.0%)
- Secondary events (primary events, unstable angina hospitalization, HF hospitalization, late CABG): adjusted for clinical risk factors, LV function, ischemia extent, infarct size
Original publication
Association of Adverse Clinical Outcomes With Peri-Infarct Ischemia Detected by Stress Cardiac Magnetic Imaging. J Am Coll Cardiol. Published 30 July 2024. doi:10.1016/j.jacc.2024.04.062
Summarised from the published abstract; every number is checked against it