Arrhythmias & electrophysiologyCohort study
Association of Atrial Fibrillation Burden and Mortality Among Patients With Cardiac Implantable Electronic Devices
- Retrospective cohort study
- claims database linked to device database
Authors' conclusion
After adjustment for potential confounding factors, the presence of AF was associated with higher mortality in our cohort of patients with cardiac implantable electronic devices. Among those with AF, nonparoxysmal AF was associated with the greatest risk of mortality.
Study context
- Population
- Patients with cardiac implantable electronic devices transmitting data ≥6 months after implantation, US claims database 2015–2020analysed
- Participants
- 21,391 patients
- Exposure
- Device-recognized atrial fibrillation (AF) vs no AF
- AFn = 7,798
- Outcome
- All-cause mortality
- Follow-up
- Mean 22.4±12.9 months
Main finding
Adjusted all-cause mortality
Hazard ratio
1.29
95% CI 1.20–1.39
P < 0.001
AF vs No AF
HR 1.29 (95% CI 1.20–1.39); P < 0.001
As reported in the abstract
- Overall incidence of mortality
- 13.5%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality by AF type (among AF) — Persistent AF vs Paroxysmal AF | 1.36 (1.18–1.58) | P < 0.001 | |
| Mortality by AF type (among AF) — Permanent AF vs Paroxysmal AF | 1.23 (1.14–1.34) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Original publication
Association of Atrial Fibrillation Burden and Mortality Among Patients With Cardiac Implantable Electronic Devices. Circulation. Published 28 June 2024. doi:10.1161/circulationaha.124.069757
Summarised from the published abstract; every number is checked against it