Cohort study
Association of Autoimmune Diseases With Coronary Atherosclerosis Severity and Ischemic Events
- Registry-based cohort study
Authors' conclusion
Autoimmune diseases were independently associated with higher burden of coronary atherosclerosis and higher risk for future ASCVD events, with risk accentuated by traditional cardiovascular risk factors.
Study context
- Population
- Patients undergoing coronary CT angiography, Western Denmark Heart Registry3,832 atherosclerotic cardiovascular disease (ASCVD) events
- Participants
- 85,512 patients
- Exposure
- Autoimmune disease vs no autoimmune disease
- Autoimmune diseasen = 4,064
- Outcome
- Coronary atherosclerosis (any plaque, any coronary artery calcification (CAC), CAC >90th percentile, obstructive CAD) and ASCVD events
- Follow-up
- 5.3 years (Q1-Q3: 2.8-8.2 years)
Main finding
As reported in the abstract
Autoimmune disease vs No autoimmune diseaseEstimate (95% CI)
any plaque
aOR 1.29(1.20–1.40)
any CAC
aOR 1.28(1.19–1.37)
CAC >90th percentile
aOR 1.53(1.39–1.68)
obstructive CAD
aOR 1.04(0.91–1.17)
ASCVD
aHR 1.46(1.29–1.65)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| ASCVD in autoimmune patients, by cardiovascular risk factor profile · ∼54% lower risk | aHR 0.46 (95% CI 0.27–0.81) | |
| Obstructive CAD · not associated | aOR 1.04 (95% CI 0.91–1.17) | |
| 0.20.5125Ratio (log scale) |
ASCVD in autoimmune patients, by cardiovascular risk factor profile
- Traditional cardiovascular risk factors strongly associated with future ASCVD events
Original publication
Association of Autoimmune Diseases With Coronary Atherosclerosis Severity and Ischemic Events. J Am Coll Cardiol. Published 25 June 2024. doi:10.1016/j.jacc.2024.04.030
Summarised from the published abstract; every number is checked against it