Heart failure & cardiomyopathiesCohort study
Association of Baseline and Longitudinal Changes in Insulin-Like Growth Factor-Binding Protein-7 with the Risk of Incident Heart Failure: Data from the PREVEND Study
- Prospective cohort study
- community-based
- PREVEND cohort
Authors' conclusion
Both baseline as well as repeat IGFBP7 measurements provide information about the risk of developing HF.
Study context
- Population
- Community-dwelling Dutch adults without prevalent heart failure (HF) (PREVEND)3,879 attended visits 2 and 4
- Participants
- 6,125 adults
- Exposure
- IGFBP7, baseline and change between visits
- Outcome
- Incident HF
- Follow-up
- Median 8.4 years
Main finding
Incident HF by baseline IGFBP7 · median 8.4 years
Hazard ratio
1.22
95% CI 1.03–1.46
Baseline IGFBP7 per 1 SD change in log-transformed IGFBP7
HR 1.22 (95% CI 1.03–1.46)
Per 1 SD change in log-transformed IGFBP7, as printed
As reported in the abstract
- Incident HF
- 194 participants (3.2%)
- Median baseline IGFBP7
- 87.0 (75.1-97.3) ng/ml
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident HF by change in IGFBP7 between visits 2 and 4 · median 3.2 years after visit 4 · adjusted for HF risk factors; n = 3879, 93 incident HF | 1.68 (1.19–2.36) | |
| 0.512Hazard ratio (log scale) |
- Incident HF by change in IGFBP7 between visits 2 and 4 — Median increase in IGFBP7 between visits
- 0.68 (−7.09 to 8.36) ng/ml
Incident HF by baseline IGFBP7, NT-proBNP <125 ng/L (subgroup)
- Baseline IGFBP7 significantly associated with incident HF
Original publication
Association of Baseline and Longitudinal Changes in Insulin-Like Growth Factor-Binding Protein-7 with the Risk of Incident Heart Failure: Data from the PREVEND Study. Eur J Heart Fail. Published 17 July 2024. doi:10.1002/ejhf.3328
Summarised from the published abstract; every number is checked against it