Cohort study
Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease
- Retrospective cohort study
- new user design
- inverse probability of treatment weighting using the propensity score
Authors' conclusion
In patients with angiographically documented stable CAD without heart failure or a recent myocardial infarction, beta-blockers were associated with a small but significant reduction in cardiovascular events at 5 years.
Study context
- Population
- Patients aged >66 years with obstructive coronary artery disease (CAD) on elective coronary angiography, Ontario, Canada, 2009–2019, without HF, recent MI or beta-blocker claim in the previous year
- Participants
- 28,039 patients
- Exposure
- Beta-blocker vs no beta-blocker
- Beta-blockern = 12,695
- Outcome
- Composite of all-cause mortality and hospitalization for HF or MI
- Follow-up
- 5 years
Main finding
As reported in the abstract
Each group vs no beta-blockerAbsolute risk reduction, % (95% CI)
Beta-blocker
−1.8(−2.8 to −0.8)
Each group vs no beta-blockerHazard ratio (95% CI)P value
Beta-blocker
0.92(0.86–0.98)
P = 0.006Observational data: associations, not effects.
Further findings
| Outcome | cause-specific HR (95% CI) | P value | |
|---|---|---|---|
| MI hospitalization | 0.87 (0.77–0.99) | P = 0.031 | |
| 0.512Cause-specific hazard ratio (log scale) |
All-cause death, HF hospitalization
- No differences observed
Original publication
Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease. J Am Coll Cardiol. Published 20 June 2023. doi:10.1016/j.jacc.2023.04.021
Summarised from the published abstract; every number is checked against it