Cardiometabolic & kidneyCross-sectional study
Association of cardiometabolic disease with subclinical cardiac remodeling in men vs. women in the Framingham Heart Study
- Cross-sectional study
Authors' conclusion
We observed that sex modifies the association of cardiometabolic disease burden with subclinical markers of cardiac dysfunction. Specifically, higher cardiometabolic disease burden was associated with worse GLS and E/e' ratio in women versus men.
Study context
- Population
- Framingham Heart Study participants54% women
- Participants
- 6,182 participants
- Exposure
- Women vs men
- Outcome
- Sex-specific association of MetSS score with echocardiographic markers of subclinical cardiac remodeling (GLS, E/e' ratio)
Main finding
As reported in the abstract
Association per 1-point increase in MetSS score
| Group | GLS ß | E/e' ratio ß |
|---|---|---|
| Women | 0.35 (SE 0.04) | 0.29 (SE 0.02) |
| Men | 0.23 (SE 0.04) | 0.20 (SE 0.02) |
- Women vs Men: pint 0.01 — GLS: 0.35% vs 0.23% higher (worse) per 1-point MetSS; interaction P
- Women vs Men: pint <0.001 — E/e' ratio; interaction P
Observational data: associations, not effects.
Original publication
Association of cardiometabolic disease with subclinical cardiac remodeling in men vs. women in the Framingham Heart Study. Eur J Prev Cardiol. Published 18 May 2026. doi:10.1093/eurjpc/zwag269
Summarised from the published abstract; every number is checked against it