Acute cardiac care & resuscitationResearch article
Association of Chest Compression Metrics During Pediatric CPR With Intra-Arrest Blood Pressure and Survival Outcomes in the United States: Insights From ICU-RESUS
- Prospectively designed embedded study within the ICU RESUScitation Project (ICU-RESUS)
- 10 intensive care units in the United States
- multivariable Poisson regression models
Authors' conclusion
Currently recommended CC rate, depth, and fraction targets were not associated with SHD in this cohort. In contrast, we identified new potential pediatric cardiopulmonary resuscitation targets that were associated with SHD: rate 130 to 160 CC/min, depths of 23 to 27 mm for patients <1 year, and CCF >90%. These criteria need validation in future prospective trials.
Study context
- Population
- Children (≤18 years) who received cardiopulmonary resuscitation in intensive care units in the United States, 2016–2021; excluded patients with documented limitations of care, who were brain dead, or who had OHCApatients with evaluable data
- Participants
- 543 children
- Comparison
- Associations between achieving chest compression (CC) targets over the first 10 minutes of cardiopulmonary resuscitation and outcomes
- Outcome
- Survival to hospital discharge [SHD]
Main finding
As reported in the abstract
Adjusted relative risk (95% CI)
Depth target
0.81(0.51–1.29)
CCF target
1.19(0.92–1.54)
- Rate target · CI as printed (single bound)
- aRR 0.91 (95% CI 0.78)
Further findings
Recommended CC targets met
SHD by exploratory targets (cubic spline analyses)
| Comparison | aRR | |
|---|---|---|
| rate 130 to 160 cm 3 /min · exploratory analyses | 1.23 (95% CI 1.04–1.46) | |
| depths of 23 to 27 mm for patients <1 year · exploratory analyses | 1.76 (CI 1.14–2.72) | |
| CCF >90% · exploratory analyses | 1.24 (CI 1.03–1.49) | |
| 0.20.5125Adjusted relative risk (log scale) |
Patient characteristics
- Mean age
- 3.6 (SD, 5.3) years
- Male
- 54.3%
Original publication
Association of Chest Compression Metrics During Pediatric CPR With Intra-Arrest Blood Pressure and Survival Outcomes in the United States: Insights From ICU-RESUS. Circ Popul Health Outcomes. Published 30 September 2026. doi:10.1161/circoutcomes.125.013037
Summarised from the published abstract; every number is checked against it