Cohort study
Association of Disrupted Delta Wave Activity During Sleep With Long-Term Cardiovascular Disease and Mortality
- Prospective cohort study
- two cohorts (SHHS, MrOS Sleep)
- multivariable Cox regression
Authors' conclusion
The results suggest that delta wave activity disruption during sleep may be a useful metric to identify those at increased risk for CVD and CVD mortality.
Study context
- Population
- Participants with overnight polysomnography in SHHS and MrOS Sleep cohortsSHHS 4,058
- Exposure
- Lower vs higher delta wave entropy during sleep
- Outcome
- Incident CVD (incl. CHD) and CVD mortality
- Follow-up
- 11.0 ± 2.8 years (SHHS); 15.5 ± 4.4 years (MrOS)
Main finding
As reported in the abstract
Lower delta wave entropy and CHD, CVD, CVD mortality
Lower delta wave entropyHazard ratio (95% CI)P value
CHD, SHHS
1.46(1.02–2.06)
P = 0.03CHD, MrOS
1.79(1.17–2.73)
P < 0.01CVD, SHHS
1.60(1.21–2.11)
P < 0.01CVD, MrOS
1.43(1.00–2.05)
P = 0.05CVD mortality, SHHS
1.94(1.18–3.18)
P < 0.01CVD mortality, MrOS
1.66(1.12–2.47)
P = 0.01- Incident cardiovascular disease (CVD), SHHS
- 729
- CVD deaths, SHHS
- 192
- Incident CVD, MrOS
- 547
- CVD deaths, MrOS
- 391
Observational data: associations, not effects.
Further findings
Predictive value vs conventional sleep parameters (Shapley Additive Explanations)
- Low delta wave entropy more predictive of CHD, CVD and CVD mortality than conventional sleep parameters
Original publication
Association of Disrupted Delta Wave Activity During Sleep With Long-Term Cardiovascular Disease and Mortality. J Am Coll Cardiol. Published 3 April 2024. doi:10.1016/j.jacc.2024.02.040
Summarised from the published abstract; every number is checked against it