Heart failure & cardiomyopathiesCohort study
Association of Extracoronary Calcification and Incident Heart Failure in the Multiethnic Study of Atherosclerosis (MESA)
- Prospective cohort study
- multiethnic
- multivariable Cox regression
Authors' conclusion
ECC is associated with increased risk for HF, in particular HFpEF.
Study context
- Population
- MESA participants with baseline CT of aortic valve, aortic root, mitral valve and thoracic aorta calcification3,617 extracoronary calcification (ECC) 0
- Exposure
- Highest vs lowest ECC quartile
- Outcome
- Incident HF, including HFpEF
- Follow-up
- Mean 12.9 ± 4.2 years
Main finding
As reported in the abstract
Incident HF and HFpEF
Highest ECC quartile vs Lowest ECC quartileAdjusted hazard ratio (95% CI)P value
incident HF; attenuated to borderline significance after adjustment for coronary artery calcification
1.72(1.16–2.55)
P = 0.007incident HFpEF; after full adjustment incl. coronary artery calcification
3.09(1.45–6.60)
P = 0.003- Heart failure (HF) events
- 358
- HF with reduced EF events
- 179
- Heart failure with preserved ejection fraction (HFpEF) events
- 135
Observational data: associations, not effects.
Original publication
Association of Extracoronary Calcification and Incident Heart Failure in the Multiethnic Study of Atherosclerosis (MESA). JACC Heart Fail. Published 26 March 2025. doi:10.1016/j.jchf.2024.12.007
Summarised from the published abstract; every number is checked against it