Heart failure & cardiomyopathiesResearch article
Association of GLP-1 receptor agonists versus bariatric surgery with outcomes in obese patients with hypertrophic cardiomyopathy: a multicenter propensity-matched analysis
- Multicenter propensity-matched analysis
- propensity score matching (1:1)
- Cox models
Authors' conclusion
In obese patients with HCM, GLP-1 RA therapy was associated with lower all-cause mortality and fewer HF events compared with BS. Future studies are warranted to confirm our findings.
Study context
- Population
- Adults with hypertrophic cardiomyopathy (HCM) and body mass index (BMI) ≥ 30 kg/m955 included in each matched cohort after matching (mean age 54 ± 13 years, 70% female, BMI 40.0 kg/m) · GLP-1 RA matched cohort 955 · bariatric surgery (BS) matched cohort 955
- Participants
- 5,002 adults
- Comparison
- GLP-1 RA vs BS
- GLP-1 RAn = 955
- BSn = 955reference
Main finding
All-cause mortality · 24 months
Hazard ratio
0.46
95% CI 0.27–0.80
P = 0.004
By group
GLP-1 RA vs BS
HR 0.46 (95% CI 0.27–0.80); P = 0.004
As reported in the abstract
Further findings
| Outcome | GLP-1 RA | BS | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| HF hospitalization · 24 months | 8.7% | 14.0% | 0.60 (0.46–0.79) | P < 0.001 | |
| Composite cardiovascular outcomes · 24 months | 10.7% | 17.2% | 0.60 (0.47–0.77) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Change, kg/m
| Outcome | GLP-1 RA | BS | Estimate | P value |
|---|---|---|---|---|
| Change in BMI · 24 months · BMI reduction was greater after bariatric surgery | −2.6 | −4.0 | P < 0.001 |
Arrhythmia and cardiovascular symptoms · 24 months
- Rates of arrhythmia and cardiovascular symptoms were comparable between the two groups
Original publication
Association of GLP-1 receptor agonists versus bariatric surgery with outcomes in obese patients with hypertrophic cardiomyopathy: a multicenter propensity-matched analysis. Eur Heart J Qual Care Clin Outcomes. Published 30 March 2026. doi:10.1093/ehjqcco/qcag051
Summarised from the published abstract; every number is checked against it