Prevention & lipidsCross-sectional study
Association of healthy dietary patterns and cardiorespiratory fitness in the community
- Cross-sectional study
- community-based
- metabolomic profiling
Authors' conclusion
Higher diet quality is associated with greater CRF cross-sectionally in a middle-aged community-dwelling sample, and metabolites highlight potential shared favourable effects on cardiometabolic health.
Study context
- Population
- Framingham Heart Study participants (54 ± 9 years, 54% female, BMI 28 ± 5 kg/m²) with cardiopulmonary exercise testing and food frequency questionnaires1,154 with metabolite profiling
- Participants
- 2,380 participants
- Exposure
- Dietary quality indices vs peak VO2
- Outcome
- Peak VO2 (CRF) by dietary indices (AHEI, MDS)
Main finding
As reported in the abstract
Peak VO2 per 1 SD higher dietary index
1 SD higher Alternative Healthy Eating Index (AHEI): greater peak VO2 (1.2 mL/kg/min), 95% CI 4.3-6.0%, P < 0.0001
5.2%
1 SD higher MDS: greater peak VO2 (1.0 mL/kg/min), 95% CI 3.6-5.3%, P < 0.0001
4.5%
Observational data: associations, not effects.
Further findings
Metabolites associated with both dietary indices and peak VO2
- Metabolites concordantly associated (FDR < 5%)
- 24
- Lower cardiorespiratory fitness (CRF) and poorer diet: C6 and C7 carnitines, C16:0 ceramide, dimethylguanidino valeric acid
- Higher CRF and favourable diet: C38:7 phosphatidylcholine plasmalogen, C38:7 and C40:7 phosphatidylethanolamine plasmalogens
- N = 1154 with metabolite profiling
Original publication
Association of healthy dietary patterns and cardiorespiratory fitness in the community. Eur J Prev Cardiol. Published 28 April 2023. doi:10.1093/eurjpc/zwad113
Summarised from the published abstract; every number is checked against it