Acute cardiac care & resuscitationCohort study
Association of High-Sensitivity Cardiac Troponin T With 30-Day and 5-Year Mortality After Cardiac Surgery
- Retrospective cohort study
- consecutive cohort
Authors' conclusion
PMI reflected by perioperative hs-cTnT release is associated with the expected 30-day mortality but not 5-year mortality.
Study context
- Population
- Patients undergoing cardiac surgery with serial perioperative high-sensitivity cardiac troponin T (hs-cTnT) measurements
- Participants
- 8,292 patients
- Exposure
- Postoperative hs-cTnT above vs below mortality-associated thresholds, by surgery type
- Outcome
- 30-day mortality and 5-year mortality, by postoperative hs-cTnT release (adjusted for EuroSCORE II)
- Follow-up
- 30 days and 5 years
Main finding
As reported in the abstract
30-day mortality, hs-cTnT above cutoff · 30 days
Coronary artery bypass grafting (CABG)
2,385 ng/L (170× URL)
hs-cTnT threshold
Aortic valve replacement (AVR)
568 ng/L (41× URL)
hs-cTnT threshold
Other cardiac surgery
1,873 ng/L (134× URL)
hs-cTnT threshold
- CABG
- HR 12.56; P < 0.001
- AVR
- HR 4.44; P = 0.004
- Other cardiac surgery
- HR 3.97; P < 0.001
Observational data: associations, not effects.
Further findings
Median peak postoperative hs-cTnT
Original publication
Association of High-Sensitivity Cardiac Troponin T With 30-Day and 5-Year Mortality After Cardiac Surgery. J Am Coll Cardiol. Published 26 September 2023. doi:10.1016/j.jacc.2023.07.011
Summarised from the published abstract; every number is checked against it