Heart failure & cardiomyopathiesCohort study
Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy
- Retrospective cohort study
- single-centre
Authors' conclusion
In symptomatic oHCM patients undergoing SM, a higher histologic score was independently associated with long-term outcomes.
Study context
- Population
- Symptomatic obstructive HCM patients undergoing surgical myectomy at a tertiary center, 2005–2018
- Participants
- 1,722 patients
- Exposure
- Histology score >5 vs ≤5
- Score >5n = 598
- Score ≤5n = 1,124reference
- Outcome
- Composite of:
- Death
- Appropriate defibrillator discharge
- Cardiac transplantation
- Follow-up
- During (5.1 ± 5.2 years)
Main finding
As reported in the abstract
5.1 ± 5.2 years
Hazard ratio
1.24
95% CI 1.03–1.54
P = 0.03
Events by group
Score >5 vs Score ≤5
HR 1.24 (95% CI 1.03–1.54); P = 0.03
Observational data: associations, not effects.
Further findings
Overall primary events and deaths · 5.1 ± 5.2 years
- Primary events
- 352 (20%)
- Deaths
- 317 [18%]
- Mean total histologic score
- 5.1 ± 1.4
Original publication
Association of Histologic Findings With Long-Term Outcomes in Symptomatic Obstructive Hypertrophic Cardiomyopathy Patients Undergoing Surgical Myectomy. JACC Heart Fail. Published 15 November 2024. doi:10.1016/j.jchf.2024.10.006
Summarised from the published abstract; every number is checked against it