Cohort study
Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans
- Prospective cohort study
- matched 1:2
- Cox proportional hazards models
Authors' conclusion
HIV infection is associated with an increased risk of AAA among those with low CD4+ T-cell counts or elevated HIV viral load over time.
Study context
- Population
- Veterans without prevalent abdominal aortic aneurysm (AAA), Veterans Aging Cohort Study2,431 incident AAA events
- Participants
- 143,001 veterans
- Exposure
- HIV vs no HIV
- People with HIV (PWH)n = 43,766
- Outcome
- Incident AAA (ICD-9/10 or CPT codes)
- Follow-up
- Median 8.7 years
Main finding
Incident AAA
Adjusted hazard ratio
1.02
95% CI 0.92–1.13
By group
PWH vs Without HIV
adjusted HR 1.02 (95% CI 0.92–1.13)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| Incident AAA by time-varying CD4+ count and HIV viral load (secondary analyses) — PWH, CD4+ <200 cells/mm3 vs Without HIV | 1.29 (1.02–1.65) | |
| Incident AAA by time-varying CD4+ count and HIV viral load (secondary analyses) — PWH, viral load ≥500 copies/mL vs Without HIV | 1.29 (1.09–1.52) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans. Circulation. Published 25 May 2023. doi:10.1161/circulationaha.122.063040
Summarised from the published abstract; every number is checked against it