Heart failure & cardiomyopathiesCohort study
Association of inflammatory markers with incident heart failure or cancer in the HUNT3 and Health and Body Composition (ABC) population studies
- Prospective cohort study
- two community-based cohorts
Authors' conclusion
A state of chronic, low-grade inflammation captured by an increase in hsCRP levels is associated with an increased risk of developing HF or cancer
Study context
- Population
- Community-based adults; HUNT3 mean age 52.3 ± 15.8 years, Health ABC mean age 72.6 ± 2.9 years
- Participants
- 47,163 vs 2,803
- Exposure
- Higher vs lower baseline high-sensitivity C-reactive protein (hsCRP)
- HUNT3n = 47,163
- Health ABCn = 2,803
- Outcome
- Incident HF or cancer
- Follow-up
- Median 12.1 years (HUNT3); 8.2 years (Health ABC)
Main finding
As reported in the abstract
HR
hsCRPHUNT3, elevated baseline hsCRP, adjusted
1.09(95% CI 1.07–1.10)
hsCRPHealth ABC, adjusted
1.11(95% CI 1.05–1.18)
IL-1Health ABC, adjusted
1.15(CI 1.07–1.24)
IL-6Health ABC, adjusted
1.09(CI 1.02–1.17)
TNF-αHealth ABC, adjusted
1.15(CI 1.07–1.24)
- HUNT3: developed heart failure (HF)
- 2034 (4.3%)
- HUNT3: developed cancer
- 5024 (10.7%)
- HUNT3: both HF and cancer
- 442 (0.9%)
- Health ABC: HF diagnosed
- 346 (12.3%)
- Health ABC: cancer diagnosed
- 776 (27.7%)
- Health ABC: both conditions
- 77 (2.7%)
Observational data: associations, not effects.
Original publication
Association of inflammatory markers with incident heart failure or cancer in the HUNT3 and Health ABC population studies. Eur J Prev Cardiol. Published 1 March 2024. doi:10.1093/eurjpc/zwae089
Summarised from the published abstract; every number is checked against it