Heart failure & cardiomyopathies
Association of innate versus specific immunity with heart failure incidence: a prospective study
Authors' conclusion
The innate immunity status markers were positively associated with HF incidence, while specific immunity status markers exhibited an inverse association, offering novel insights for HF prediction and intervention.
Study context
- Population
- UK Biobank participants
- Participants
- 330,362 participants
- Exposure
- Innate vs specific immunity status markers
- Outcome
- Incident HF
- Follow-up
- Median 14.1 years
Methodological detailsUK Biobank, Cox proportional hazard models; flexible parametric survival models; subgroup analyses by age, sex and BMI; sensitivity analyses
- UK Biobank
- Cox proportional hazard models; flexible parametric survival models; subgroup analyses by age, sex and BMI; sensitivity analyses
Main finding
As reported in the abstract
Incident HF, fully adjusted HR per SD increment
Hazard ratio (95% CI)
Neutrophils (per SD)innate
1.20(1.17–1.22)
Monocytes (per SD)innate
1.09(1.07–1.12)
SII (per SD)innate
1.12(1.10–1.14)
NLR (per SD)innate
1.16(1.14–1.18)
Platelets (per SD)
0.97(0.95–1.00)
Lymphocytes (per SD)specific
0.97(0.95–0.99)
LMR (per SD)specific
0.90(0.88–0.92)
Per SD, as printed
- Participants developing heart failure (HF)
- 9611 (2.9%)
Observational data: associations, not effects.
Original publication
Association of innate versus specific immunity with heart failure incidence: a prospective study. Heart. Published 1 November 2024. doi:10.
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