Cohort study
Association of Left Atrial Strain With Ischemic Stroke Risk in Older Adults
- Prospective cohort study
Authors' conclusion
This cohort study suggests that reduced positive longitudinal LAε and negative longitudinal LASR are independently associated with ischemic stroke in older adults.
Study context
- Population
- Adults aged ≥55 years without prior stroke or atrial fibrillation (AF), Northern Manhattan Study
- Participants
- 806 adults
- Exposure
- Lowest vs all other quintiles of left atrial (LA) strain and LA strain rate
- Outcome
- Incident ischemic stroke
- Follow-up
- Mean (SD) 10.9 (3.7) years
Main finding
As reported in the abstract
Lowest quintile vs All other quintilesEstimate (95% CI)
positive longitudinal LA strain
adjusted HR 3.12(1.56–6.24)
negative longitudinal LA strain rate during LA contraction
HR 2.89(1.44–5.80)
- Ischemic stroke overall
- 53 participants (6.6%)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident ischemic stroke, normal LA size (subgroup) — Lowest quintile vs All other quintiles · positive longitudinal LA strain | 4.64 (1.55–13.89) | |
| Incident ischemic stroke, normal LA size (subgroup) — Lowest quintile vs All other quintiles · negative longitudinal LA strain rate during LA contraction | 11.02 (3.51–34.62) | |
| 0.050.21520Hazard ratio (log scale) |
Incident AF
- Incident AF
- 103 participants (12.8%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Left Atrial Strain With Ischemic Stroke Risk in Older Adults. JAMA Cardiol. Published 1 April 2023. doi:10.1001/jamacardio.2022.5449
Summarised from the published abstract; every number is checked against it