Arrhythmias & electrophysiologyCohort study
Association of Life’s Essential 8 and incident cardiac conduction disorder: a prospective cohort study
- Prospective cohort study
- UK Biobank
Authors' conclusion
Higher LE8 scores were associated with a lower risk of CCD, including severe conduction block requiring pacemaker implantation and left bundle branch or fascicular block.
Study context
- Population
- Adults from the UK Biobank free of CVD at baseline2,760 cardiac conduction disorders (CCD) cases
- Participants
- 112,160 adults
- Exposure
- High vs moderate vs low cardiovascular health (CVH)
- Outcome
- Incident cardiac conduction disorders (CCD)
- Follow-up
- Median 11.6 years
Main finding
Incident CCD
Hazard ratio
0.48
95% CI 0.40–0.56
High CVH vs Low CVH
HR 0.48 (95% CI 0.40–0.56)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Severe conduction block | 0.63 (0.52–0.78) | |
| Left bundle branch or fascicular block | 0.35 (0.25–0.49) | |
| 0.20.5125Hazard ratio (log scale) |
Individual LE8 metrics (WQS analysis)
- BMI and sleep health were the major contributors to reduced CCD risk
Original publication
Association of Life’s Essential 8 and incident cardiac conduction disorder: a prospective cohort study. Eur J Prev Cardiol. Published 20 February 2025. doi:10.1093/eurjpc/zwaf089
Summarised from the published abstract; every number is checked against it