Association of Life's Essential 8 With Clonal Hematopoiesis and Coronary Artery Disease
Authors' conclusion
Optimal cardiovascular health is associated with a lower prevalence of CH. Although maintaining ideal cardiovascular health is associated with lower CAD risk in CH carriers, this protective benefit is attenuated compared with noncarriers.
Study context
- Population
- UK Biobank participants
- Participants
- 427,295 UK Biobank participants
- Comparison
- LE8 score and clonal hematopoiesis (CH); their joint effects on incident coronary artery disease (CAD)
Main finding
As reported in the abstract
CH prevalence
CH prevalence
3.4%
Further findings
| Outcome | Values | Estimate | P value | |
|---|---|---|---|---|
| Odds of CH and driver mutations per higher LE8 score · ASXL1; strongest association | OR 0.79 (95% CI 0.75–0.83) | P < 0.001 | ||
| Incident CAD per 1-SD increase in LE8, by CH status · median 13.6-year follow-up — 1-SD increase in LE8 · in CH carriers | adjusted HR 0.74 (95% CI 0.70–0.78) | |||
| Incident CAD per 1-SD increase in LE8, by CH status · median 13.6-year follow-up — 1-SD increase in LE8 · in noncarriers | adjusted HR 0.68 (95% CI 0.67–0.69) | |||
| 0.512Ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| Absolute CAD risk · highest absolute CAD risk | ASXL1 CH subtype and low LE8 scores 18.7 events/1,000 person-years · noncarriers with high LE8 2.0 events/1,000 person-years |
- Incident CAD per 1-SD increase in LE8, by CH status: Pinteraction = 0.005
- Incident CAD per 1-SD increase in LE8, by CH status: CH significantly modified the protective effect of LE8 on CAD incidence on multiplicative and additive scales
Odds of CH and driver mutations per higher LE8 score
- A higher LE8 score was associated with significantly lower odds of CH and examined driver mutations
Original publication
Association of Life's Essential 8 With Clonal Hematopoiesis and Coronary Artery Disease. JACC CardioOncol. Published 15 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it