Coronary disease & ACSCohort study
Association of longitudinal triglyceride levels with cardiovascular events in multivessel coronary artery disease
- Cohort study
- registry
Authors' conclusion
Increased upward variation of longitudinal fasting triglyceride levels was independently associated with higher rates of cardiovascular outcomes in patients with multivessel CAD. This association was especially observed in individuals with previously controlled triglyceride levels but not in those with elevated baseline levels.
Study context
- Population
- Patients with multivessel Coronary Artery Disease (CAD), MASS Registry, Heart Institute, University of São Paulo, June 1995 to March 2010886 with complete data
- Participants
- 1,020 patients
- Exposure
- Per 100 mg/dL increase in longitudinal fasting TG levels
- Outcome
- Composite of:
- Death
- MI
- Ischaemic stroke
- Unplanned myocardial revascularization
- Follow-up
- Mean 10.0 years
Main finding
As reported in the abstract
Composite of:
- Death
- MI
- Ischaemic stroke
- Unplanned myocardial revascularization (357 events)
longitudinal triglyceride levelsHazard ratio (95% CI)P value
per 100 mg/dL increase; unadjusted
1.19(1.05–1.34)
P = 0.008per 100 mg/dL increase; multivariable adjusted
1.26(1.10–1.41)
P < 0.001Per 100 mg/dL increase, as printed
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Composite endpoint per 100 mg/dL TG increase, by baseline TG (subgroup) — < 150 mg/dL · baseline TG <150 mg/dL; multivariable adjusted | 1.49 (1.00–1.93) | P = 0.029 | |
| Composite endpoint per 100 mg/dL TG increase, by baseline TG (subgroup) — ≥ 150 mg/dL · baseline TG ≥150 mg/dL; multivariable adjusted | 1.15 (0.99–1.39) | P = 0.214 | |
| 0.512Hazard ratio (log scale) |
Original publication
Association of longitudinal triglyceride levels with cardiovascular events in multivessel coronary artery disease. Eur J Prev Cardiol. Published 2 June 2025. doi:10.1093/eurjpc/zwaf192
Summarised from the published abstract; every number is checked against it