Prevention & lipidsCohort study
Association of Lp(a) With Cardiovascular Disease and All-Cause Mortality in U.S. Hispanics and Latinos
- Prospective cohort study
- multivariable Cox models
- sampling weights and survey methods
Authors' conclusion
Hispanic/Latino individuals with elevated Lp(a) are at an increased risk of MI and all-cause mortality.
Study context
- Population
- Hispanic/Latino adults in the US (Hispanic Community Health Study/Study of Latinos)
- Participants
- 16,117 adults
- Exposure
- Lp ≥125 nmol/L vs <125 nmol/L; Lp quintiles; log-transformed Lp
- Outcome
- MI, ischemic stroke and all-cause mortality
- Follow-up
- Median 9.8 years
Main finding
As reported in the abstract
Lp(a) ≥125 nmol/L vs Lp(a) <125 nmol/LHazard ratio (95% CI)
MI
2.29(1.45–3.63)
all-cause mortality
1.43(1.05–1.93)
composite events
1.56(1.22–2.01)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MI per 1-SD increase in log-transformed Lp(a) | 1.47 (1.14–1.89) | |
| 0.512Hazard ratio (log scale) |
Highest Lp(a) quintile (>77 nmol/L) vs lower 4 quintiles
- Elevated risk observed only for myocardial infarction (MI) and composite events
Lp(a) distribution and event rates
- Median Lp(a) (Q1-Q3: 7.3-60.6 nmol/L)
- 19.7 nmol/L
- Lp(a) ≥125 nmol/L
- 11.4%
- Events (135 MI, 99 stroke, 649 all-cause mortality)
- 883
- Age-adjusted incidence rate of composite events
- 505.2 per 100,000 person-years
Original publication
Association of Lp(a) With Cardiovascular Disease and All-Cause Mortality in U.S. Hispanics and Latinos. J Am Coll Cardiol. Published 9 December 2025. doi:10.1016/j.jacc.2025.09.1605
Summarised from the published abstract; every number is checked against it