Coronary disease & ACSCohort study
Association of neutrophil-to-lymphocyte ratio with clinical outcomes after percutaneous coronary intervention
- Retrospective cohort study
- single-centre
Authors' conclusion
Baseline NLR is associated with adverse cardiovascular outcomes in CAD patients undergoing PCI.
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI) for chronic coronary syndrome or acute coronary syndrome (ACS) at Mount Sinai Hospital, 2012–2022
- Participants
- 7,287 patients
- Exposure
- Neutrophil-to-lymphocyte ratio (NLR) quartiles
- Outcome
- MACE:
- All-cause death
- Myocardial infarction (MI)
- Stroke
- Follow-up
- 1 year
Main finding
MACE
Adjusted hazard ratio
1.52
95% CI 1.12–2.05
By group
4th quartile vs 1st quartile
adjHR 1.52 (95% CI 1.12–2.05)
As reported in the abstract
- MACE incidence increased across NLR quartiles (P for trend)
- 0.004
Observational data: associations, not effects.
Further findings
| Outcome | adjHR (95% CI) | |
|---|---|---|
| All-cause death · 1 year | 1.71 (1.10–2.65) | |
| MI · 1 year | 1.53 (1.00–2.35) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Ischaemic risk by subgroup
- Ischaemic risk with high NLR more pronounced in ACS and chronic kidney disease (CKD)
Safety
| Outcome | adjHR (95% CI) | |
|---|---|---|
| Bleeding · 1 year | 2.01 (1.50–2.70) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of neutrophil-to-lymphocyte ratio with clinical outcomes after percutaneous coronary intervention. Eur J Prev Cardiol. Published 1 October 2025. doi:10.1093/eurjpc/zwaf597
Summarised from the published abstract; every number is checked against it