Valvular & structural heart diseaseCohort study
Association of NT-proBNP With Clinical Outcomes in Patients Undergoing Transcatheter Tricuspid Valve Intervention
- cohort
Authors' conclusion
In patients undergoing TTVI, baseline NT-proBNP levels and early postprocedural increases in NT-proBNP identify individuals at high risk for long-term mortality but do not predict symptomatic improvement. NT-proBNP reflects residual myocardial stress rather than procedural success and may aid in patient selection and early postinterventional surveillance.
Study context
- Population
- Patients with severe tricuspid regurgitation undergoing transcatheter tricuspid valve intervention (TTVI)
- Exposure
- Baseline NT-proBNP levels and early postinterventional NT-proBNP changes (baseline to 4-week follow-up) in relation to long-term all-cause mortality and NYHA functional class improvement
Main finding
As reported in the abstract
- Higher baseline NT-proBNP levels were independently associated with increased long-term all-cause mortality
Observational data: associations, not effects.
Secondary outcomes
Survival by early NT-proBNP change · 4 weeks
- Patients with increasing NT-proBNP levels at 4 weeks showed markedly worse survival, irrespective of procedural success
NYHA functional class improvement (≥1 class) (secondary endpoint) · 4 weeks
- Baseline NT-proBNP was not associated with symptomatic improvement according to NYHA functional class
Baseline right atrial characteristics in patients with increasing NT-proBNP
- Larger right atrial volumes and higher right atrial pressures at baseline
Original publication
Summarised from the published abstract; every number is checked against it