Prevention & lipidsCross-sectional study
Association of Objective Physical Activity and Mortality in American Heart Association’s Life’s Essential 8
- National Health and Nutrition Examination Survey (2011-2012) participants who wore wrist-worn accelerometers
Authors' conclusion
Higher AHA LE8 scores, with objective measures of PA, are associated with reduced mortality. Objective PA was not associated with all-cause mortality when accounting for behavioral and metabolic health factors.
Study context
- Population
- National Health and Nutrition Examination Survey (2011–2012) participants who wore wrist-worn accelerometers, with mortality linked from the National Death Indexparticipants included
- Participants
- 2,918 participants
- Exposure
- association between accelerometer physical activity (PA) measures and American Heart Association's (AHA) LE8 + objective PA measures with all-cause and cause-specific mortality
Main finding
As reported in the abstract
All-cause mortality, higher percentile PA categories
OR, unadjusted
0.43; 95% CI: 0.36-0.52
OR, adjusted for behavioral and metabolic factors (no statistical significance)
0.86; 95% CI: 0.43-1.70
Observational data: associations, not effects.
Further findings
All-cause mortality, higher LE8 scores
- OR, 50th percentile PA cutoff
- 0.77; 95% CI: 0.68-0.88
- OR, 75th percentile PA cutoff
- 0.81; 95% CI: 0.71-0.94
- higher LE8 scores correlated with reduced all-cause mortality risk
Discrimination of PA for mortality
- AUC, all-cause mortality (moderate discriminatory power)
- 0.746
- Not discriminatory for cause-specific mortality
Original publication
Association of Objective Physical Activity and Mortality in American Heart Association’s Life’s Essential 8. JACC Adv. Published 27 January 2026. doi:10.1016/j.jacadv.2025.102580
Summarised from the published abstract; every number is checked against it