Coronary disease & ACSMeta-analysis
Association of Pericoronary Adipose Attenuation With Major Adverse Cardiovascular Events and High-Risk Plaque
- Systematic review and meta-analysis
- random effects
Authors' conclusion
Although the strength of associations varied by measurement technique, PCAT is associated with MACE and high-risk plaque.
Study context
- Population
- Patients undergoing coronary CT angiography; quantitative analysis in stable CAD
- Participants
- 10,482 patients · 17 studies
- Comparison
- Elevated pericoronary adipose tissue (PCAT) attenuation by coronary artery
- Outcome
- Association of PCAT attenuation with major adverse cardiac events (MACE) and high-risk plaque (HRP)
Pooled result
As reported in the abstract
MACE (univariable HR)
Hazard ratio (95% CI)P value
RCA-PCAT
1.22(1.08–1.38)
P = 0.001LCx-PCATweak significance
1.03(1.01–1.05)
P = 0.014LAD-PCATdid not meet significance
1.01(0.98–1.05)
P = 0.47Further pooled results
High-risk plaque (HRP) (qualitative synthesis)
- Positive, significant association of RCA-PCAT with HRP (HR range)
- 1.03-5.62
- No quantitative synthesis possible for HRP
Original publication
Association of Pericoronary Adipose Attenuation With Major Adverse Cardiovascular Events and High-Risk Plaque. JACC Cardiovasc Imaging. Published 10 July 2025. doi:10.1016/j.jcmg.2025.04.008
Summarised from the published abstract; every number is checked against it