Heart failure & cardiomyopathiesCross-sectional study
Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study
- Cross-sectional and prospective cohort study (ARIC)
- community-based
- multivariable linear regression adjusted for demographics and CV risk factors
Authors' conclusion
Among older adults, pulmonary vascular arterial remodeling is associated with greater left ventricular remodeling, worse diastolic and systolic dysfunction, greater pulmonary artery systolic pressure, greater odds of significant dyspnea, and greater risk of heart failure development.
Study context
- Population
- Older adults in the community-based ARIC study with echocardiography and noncontrast cardiac CT at visit 7 (2018–2019)
- Participants
- 2,275 adults
- Exposure
- Pulmonary vascular arterial remodeling (distal pruning, proximal dilation) and cardiac structure/function, pulmonary pressure and HF
- Outcome
- Associations of aBV5/aTBV (distal pruning) and aBVg10/aTBV (proximal dilation) with echocardiographic cardiac structure and function and pulmonary artery systolic pressure
Main finding
As reported in the abstract
Mean aBV5/aTBV
0.30±0.08
Mean aBVg10/aTBV
0.45±0.09
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident HF · 4-year follow-up · per one SD in aBVg10/TBV | 1.25 (1.03–1.51) | |
| 0.512Hazard ratio (log scale) |
NT-proBNP and moderate to severe dyspnea
- Lower aBV5/aTBV and higher aBVg10/aTBV associated with higher NT-proBNP and greater odds of moderate to severe dyspnea
Original publication
Association of Pulmonary Vascular Remodeling With Cardiac Structure and Function, Pulmonary Pressure, and Heart Failure in Late Life: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation. Published 21 July 2026. doi:10.1161/circulationaha.125.077856
Summarised from the published abstract; every number is checked against it