Cardio-oncology & otherCohort study
Association of radiation dose to cardiac substructures with major ischaemic events following breast cancer radiotherapy
- Retrospective cohort study
Authors' conclusion
Risk of major ischaemic events exist in the era of modern radiotherapy. LV V25 ≥ 4% appeared to be the optimum parameter and was superior to MHD in predicting major ischaemic events.
Study context
- Population
- Women with breast cancer receiving adjuvant radiotherapy
- Participants
- 2,158 women
- Exposure
- Radiation dose to cardiac substructures and major ischaemic events
- Outcome
- Major ischaemic event
Main finding
As reported in the abstract
Major ischaemic events · median follow-up 7.9 years (IQR 5.6-10.8 years)
Patients developing major ischaemic events
89
Cumulative incidence significantly higher in left-sided disease
P = 0.044
Mean heart dose (MHD) increased risk by 6.2% per Gy, HR 1.062 (95% CI 1.01-1.12)
P = 0.012
Observational data: associations, not effects.
Further findings
Other risk factors for major ischaemic events
- Age, CKD and hyperlipidaemia were significant risk factors
Original publication
Association of radiation dose to cardiac substructures with major ischaemic events following breast cancer radiotherapy. Eur Heart J. Published 16 August 2023. doi:10.1093/eurheartj/ehad462
Summarised from the published abstract; every number is checked against it