Valvular & structural heart diseaseCohort study
Association of systemic inflammatory indicators with incident valvular heart disease: a prospective analysis of the UK Biobank
- Prospective cohort study
- UK Biobank
Authors' conclusion
Systemic inflammatory indices, particularly SIRI and LMR, were independently associated with incident AS, MR, and valve-related events, whereas no clear association was detected for AR.
Study context
- Population
- UK Biobank participants free of CVD, valvular heart disease and autoimmune disease at baseline
- Participants
- 250,532 participants
- Exposure
- Systemic inflammatory indicators and incident valvular heart disease
- Outcome
- Incident aortic stenosis (AS), mitral regurgitation (MR), aortic regurgitation (AR) and valve-related events
- Follow-up
- Median 13.22 years
Main finding
As reported in the abstract
Incident AS, MR, AR and valve-related events
Estimate
Higher SIRIAS
HR per 1-SD 1.07(95% CI 1.03–1.11)
Higher SIRIMR
HR per 1-SD 1.10(95% CI 1.05–1.14)
Higher SIRIvalve-related events
HR per 1-SD 1.08(95% CI 1.03–1.13)
Higher LMRAS
HR 0.91(CI 0.86–0.96)
Higher LMRMR
HR 0.93(CI 0.89–0.98)
Higher LMRvalve-related events
HR 0.88(CI 0.82–0.94)
Observational data: associations, not effects.
Further findings
Dose-response, subgroup and sensitivity analyses
- Patterns broadly consistent
Original publication
Association of systemic inflammatory indicators with incident valvular heart disease: a prospective analysis of the UK Biobank. Eur J Prev Cardiol. Published 13 July 2026. doi:10.1093/eurjpc/zwag362
Summarised from the published abstract; every number is checked against it